AustralieFrV1, Main, Exploration, bibRecord, 006A52

Hepatitis C Pharmacogenetics: State of the Art in 2010

Identifieur interne : 006A52 ( Main/Exploration ); précédent : 006A51; suivant : 006A53

Hepatitis C Pharmacogenetics: State of the Art in 2010

Auteurs : Nezam H. Afdhal [États-Unis] ; John G. Mchutchison [États-Unis] ; Stefan Zeuzem [Allemagne] ; Alessandra Mangia [Italie] ; Jean-Michel Pawlotsky [France] ; Jeffrey S. Murray [États-Unis] ; Kevin V. Shianna [États-Unis] ; Yasuhito Tanaka [Japon] ; David L. Thomas [États-Unis] ; David R. Booth [Australie] ; David B. Goldstein [États-Unis]

Source :

Hepatology : (Baltimore, Md.) [ 0270-9139 ] ; 2011.

RBID : Pascal:11-0138008

Descripteurs français

Pascal (Inist)
- Hépatite virale C, Pharmacogénétique, Gastroentérologie.

English descriptors

KwdEn :
- Gastroenterology, Pharmacogenetics, Viral hepatitis C.

Abstract

In 2009, a correlated set of polymorphisms in the region of the interleukin-28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon-alfa and ribavirin. The same polymorphisms were subsequently associated with spontaneous clearance of HCV in untreated patients. The link between IL28B genotype and HCV clearance may impact decisions regarding initiation of current therapy, the design and interpretation of clinical studies, the economics of treatment, and the process of regulatory approval for new anti-HCV therapeutic agents.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">In 2009, a correlated set of polymorphisms in the region of the interleukin-28B (IL28B) gene were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with pegylated interferon-alfa and ribavirin. The same polymorphisms were subsequently associated with spontaneous clearance of HCV in untreated patients. The link between IL28B genotype and HCV clearance may impact decisions regarding initiation of current therapy, the design and interpretation of clinical studies, the economics of treatment, and the process of regulatory approval for new anti-HCV therapeutic agents.</div>
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Hepatitis C Pharmacogenetics: State of the Art in 2010

Hepatitis C Pharmacogenetics: State of the Art in 2010

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri